(3-Phenylphenyl)boronic acid → HCID 44450397, compound

HRID 857426Notes

Reaction equation

HRID 857426 reaction equation
[C:1]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[C:3](B(O)O)[CH:2]=1.C[CH:17]([CH:21]1[C:25]2=[C:26](Br)[C:27]3[C:28]([S:34]([CH3:37])(=[O:36])=[O:35])=[CH:29][C:30]([F:33])=[CH:31][C:32]=3[N:24]2[CH2:23][CH2:22]1)[C:18]([O-:20])=[O:19]>>[C:1]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[C:3]([C:26]2[C:27]3[C:28]([S:34]([CH3:37])(=[O:36])=[O:35])=[CH:29][C:30]([F:33])=[CH:31][C:32]=3[N:24]3[CH2:23][CH2:22][CH:21]([CH2:17][C:18]([OH:20])=[O:19])[C:25]=23)[CH:2]=1

Participants

3

Reactant 2

HCID 2734315(3-Phenylphenyl)boronic acidHCID 131726153HCID 131726153, compound

Product 1

HCID 44450397HCID 44450397, compound

Procedure

Starting from 1,1′-biphenyl-3-ylboronic acid and (+/−)-methyl[9-bromo-6-fluoro-8-(methylsulfonyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate (Example 126, Step 1), the title compound was synthesized following the procedures described in Step 2 of Example 126 and Step 10 of Example 7.

Sources & evidence

ORD record
ord-5caa6a058f1d4e80a52af1b256684402
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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