Tetrahydrofuran → HCID 131726154, compound

Participants

Reaction Steps

A solution of the compound of Step 1 in THF (10 mL) was treated with an excess of CH2N2 at 0° C. The reaction mixture was stirred for 5 minutes and the solvent removed. The residue was purified by silica gel chromatography eluted with 50% EtOAc/hexane to give 65 mg of (+/−)-methyl[9-[(4-chlorophenyl)thio]-8-isopropyl-6-(2-methyl-2H-tetrazol-5-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate and 150 mg of (+/−)-methyl[9-[(4-chlorophenyl)thio]-8-isopropyl-6-(1-methyl-1H-tetrazol-5-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate.

Provenance & Evidence