Lithium Hydroxide → HCID 10184927, compound

Participants

Reaction Steps

The ethyl ester (65 mg) from Step 1 was dissolved in 2 mL of old (peroxide containing) 1,4-dioxane. 1 N LiOH was added (0.25 mL) and the mixture was stirred at room temperature for 2 h. Excess 1 N NaH2PO4 was added and the mixture was extracted with EtOAc (2×). The combined organic layers were washed with brine, dried over MgSO4 and concentrated in vacuo. Purification by silica gel chromatography on preparative plates eluting with 25% EtOH/CH2CL2+3% AcOH gave the desired compound (32 mg).

Provenance & Evidence