HCID 21868451, compound → HCID 21868438, compound

HRID 857574Notes

Reaction equation

HRID 857574 reaction equation
FC(F)(F)C(O)=O.[S:8]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[N:10]=[C:9]1[S:17]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][C:21]1=[O:26])(=[O:19])=[O:18].[CH3:27][O:28][C:29]1[CH:30]=[C:31]([CH:50]=[CH:51][C:52]=1[O:53][CH3:54])[CH2:32][O:33][C:34]([NH:36][C:37]1[N:45]=[CH:44][N:43]=[C:42]2[C:38]=1[N:39]=[CH:40][N:41]2[CH2:46][C:47](O)=[O:48])=[O:35]>>[S:8]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[N:10]=[C:9]1[S:17]([N:20]1[CH2:25][CH2:24][N:23]([C:47](=[O:48])[CH2:46][N:41]2[CH:40]=[N:39][C:38]3[C:42]2=[N:43][CH:44]=[N:45][C:37]=3[NH:36][C:34]([O:33][CH2:32][C:31]2[CH:50]=[CH:51][C:52]([O:53][CH3:54])=[C:29]([O:28][CH3:27])[CH:30]=2)=[O:35])[CH2:22][C:21]1=[O:26])(=[O:19])=[O:18]

Participants

3

Reactant 2

HCID 21868451HCID 21868451, compoundHCID 685235511-(Benzothiazole-2-sulfonyl)-piperazin-2-one trifluoroacetic acid salt

Product 1

HCID 21868438HCID 21868438, compound

Procedure

The title compound was synthesized by the reaction of 1-(benzothiazole-2-sulfonyl)-piperazin-2-one trifluoroacetic acid salt with [6-N-(3,4-dimethoxybenzyloxycarbonyl)-adenine-9-yl]-acetic acid as per the procedure of Example 52. 1H NMR (500 MHz; DMSO-d6) δ 10.58 (s, 1H), 8.58 (s, 0.6H), 8.56 (s, 0.4H), 8.35 (m, 1H), 8.30 (s, 0.4H), 8.27 (s, 0.6H), 8.26 (m, 1H), 7.73 (m, 2H), 7.07 (s, 1H), 6.98 (d, 1H), 6.94 (d, 1H), 5.38 (s, 1.2H), 5.27 (s, 0.8H), 5.12 (s, 2H), 4.56 (s, 0.8H), 4.28 (m, 2.4H), 4.09 (t, 2H), 3.87 (t, 0.8H), 3.76 (s, 3H), 3.74 (s, 3H).

Sources & evidence

ORD record
ord-f7b4e4a7afe84a3c9a53a6f4b23451d2
Source dataset
uspto-grants-2006_12
Patent number
US07145006B2

Reaction notes

Loading…