Dimethyl Sulfoxide → HCID 9834421, compound

Participants

Reaction Steps

Sulfur trioxide (4.84 g, 60.5 mmol) in dichloromethane (10 mL) was added to dimethyl sulfoxide (4.84 g, 62.0 mmol) in dichloromethane (10 mL) at −5 to 0° C. When the addition was complete 4-(trifluoromethyl)aniline (5.00 g, 31.0 mmol) was added dropwise. The mixture was allowed to warm to ambient temperature. After about 1 h the mixture was diluted with dichloromethane (80 mL) and washed with sodium hydroxide (1 N, 100 mL), dried and evaporated to give the title product as a solid (6.58 g, 96% yield).

Provenance & Evidence