tert-Butyl 7-benzyl-1-oxa-4,7-diazaspiro[5.4]decane-4-carboxylate → tert-Butyl 1-oxa-4,7-diazaspiro[5.4]decane-4-carboxylate

Participants

Reaction Steps

13.7 g (41 mmol) of tert-butyl 7-benzyl-1-oxa-4,7-diazaspiro[5.4]decane-4-carboxylate are dissolved in 300 ml of methanol, 3.0 g of 10% palladium on activated carbon are added, and hydrogenation is carried out at 100° C. and 100 bar. The catalyst is filtered off with suction, the filtrate is concentrated, and residue is distilled under high vacuum. 7.6 g (75% of theory) of the product are obtained.

Provenance & Evidence