HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Quinolinol, 2-methoxy- → 2-Methoxy-8-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Quinolinol, 2-methoxy- | HCID 762719 | — |
| Reactant | 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine | HCID 16747837 | — |
| Product | 2-Methoxy-8-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)quinoline | HCID 16748210 | — |
Reaction Steps
The title compound was prepared from 4-chloro-6-(4-trifluoromethyl-phenyl)-pyrimidine (Example 2(a), Method A) and 2-methoxy-quinolin-8-ol (prepared according to Ataev, A; et al. Teoreticheskaya i Eksperimental'naya Khimya 1980, 16(2), 243–249) under the conditions of Example 6. Mp: 158.5–161° C. MS (ESI, pos. ion) m/z: 398 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07144888B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-e9edfbe98e654bc39661bdeb4d88072f |
| Source note | uspto-grants-2006_12 |