HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine → 8-({6-[4-(Trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)isoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine | HCID 16747837 | — |
| Reactant | 8-Hydroxyisoquinoline | HCID 135441711 | — |
| Product | 8-({6-[4-(Trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)isoquinoline | HCID 10384316 | — |
Reaction Steps
The title compound was prepared from 4-chloro-6-(4-trifluoromethyl-phenyl)-pyrimidine (Example 2(a), Method A) and isoquinolin-8-ol (MonomerChem) under the conditions of Example 6. Mp: 194–195° C. MS (ESI, pos. ion m/z: 3682. (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07144888B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-35248ba70656446ea38c241967574279 |
| Source note | uspto-grants-2006_12 |