4-Cyanophenylboronic acid → HCID 21865241, compound

HRID 857656Notes

Reaction equation

HRID 857656 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([O:8][C:9]2[CH:10]=[CH:11][CH:12]=[C:13]3[C:18]=2[N:17]=[C:16]([NH2:19])[CH:15]=[CH:14]3)[CH:3]=1.[C:20]([C:22]1[CH:27]=[CH:26][C:25](B(O)O)=[CH:24][CH:23]=1)#[N:21]>>[NH2:19][C:16]1[CH:15]=[CH:14][C:13]2[C:18](=[C:9]([O:8][C:4]3[N:5]=[CH:6][N:7]=[C:2]([C:25]4[CH:26]=[CH:27][C:22]([C:20]#[N:21])=[CH:23][CH:24]=4)[CH:3]=3)[CH:10]=[CH:11][CH:12]=2)[N:17]=1

Participants

3

Reactant 2

HCID 27343264-Cyanophenylboronic acidHCID 21865182HCID 21865182, compound

Product 1

HCID 21865241HCID 21865241, compound

Procedure

According to the procedure described for Example 124(b), 8-(6-chloro-pyrimidin-4-yloxy)-quinolin-2-ylamine, (Example 124(a)), (0.20 g, 0.73 mmol) and 4-cyanophenylboronic acid (0.16 g, 1.1 mmol, Aldrich) provided the title compound as a white solid. Mp: 234–236° C. MS (ESI, pos. ion.) m/z:340 (M+1).

Sources & evidence

ORD record
ord-79571d6a708c4e3783a603be2d65b8ca
Source dataset
uspto-grants-2006_12
Patent number
US07144888B2

Reaction notes

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