Sodium Hydroxide → 2-(1H-imidazol-2-yl)benzonitrile

HRID 857701Notes

Reaction equation

HRID 857701 reaction equation
Cl.[NH:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]1[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=1[C:9]#[N:10].[OH-].[Na+]>O>[NH:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]1[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=1[C:9]#[N:10]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 218661592-(1H-IMIDAZOL-2-YL)-BENZONITRILE HCL

Product 1

HCID 114010062-(1H-imidazol-2-yl)benzonitrile

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 2-(1H-imidazol-2-yl)-benzonitrile hydrochloride (3 g, 0.014 mol) in water (20 ml) was added sodium hydroxide solution (2.5 N, 5 ml). Filtration of the resultant precipitate and recrystallization from ethyl acetate gave 2-(1H-imidazol-2-yl)-benzonitrile; Anal. Calcd. For C10H7N3: C, 70.99; H, 4.17; N, 24.84. Found: C, 70.74; H, 4.08; N, 25.24.

Workup

  1. filtrationFiltration of the resultant precipitate and recrystallization from ethyl acetate

Sources & evidence

ORD record
ord-3d73e31051994e19a45e7161bbba3351
Source dataset
uspto-grants-2006_12
Patent number
US07144899B2

Reaction notes

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