Water → 5-Chloro-2-(1H-tetrazol-1-YL)benzonitrile

Participants

Reaction Steps

To a solution of 5-chloro-2-(1H-tetrazol-1-yl)benzamide (1.0 g, 4.5 mmol) in THF (29 mL) was added (methoxycarbonylsulfamoyl)ammonium hydroxide, inner salt (2.1 g, 8.8 mmol) in five portions over 5 h. Water was added and the reaction mixture was extracted with ethyl acetate. The combined organic layers were washed with brine. Drying and solvent evaporation gave 5-chloro-2-tetrazol-1-yl-benzonitrile (0.83 g, 90%); 1H NMR (400 MHz, CDCl3): δ 9.26 (s, 1H), 7.90 (d, J=1.0 Hz, 1H,), 7.85 (m, 2H).

Provenance & Evidence