Trifluoroacetic acid → HCID 69655848, compound

Participants

Reaction Steps

The nonpolar isomer tert-butyl 1-[(3-chlorophenyl)(hydroxy)pyridin-3-ylacetyl]-L-prolinate (0.087 g, 0.21 mmol) was dissolved in dichloromethane (4 mL) and trifluoroacetic acid (1 mL) and stirred at room temperature for 4 hours. Then the mixture was evaporated in vacuo and vacuum dried to yield the nonpolar isomer of 1-[(3-chlorophenyl)(hydroxy)pyridin-3-ylacetyl]-L-proline (0.04 g, HPLC RT=2.51 min, Method A; LCMS m/z=361).

Provenance & Evidence