Trifluoroacetic acid → HCID 58760126, compound

Participants

Reaction Steps

TFA (5 mL) was added to a solution of tert-butyl({(1R)-2-[(2S)-2-({[5-chloro-2-(1H-1,2,4-triazol-1-yl)benzyl]amino}carbonyl)azetidin-1-yl]-1-cyclohexyl-2-oxoethyl}amino)acetate (22 mg, 0.04 mmol) in CH2Cl2 (5 mL) at 0° C. After stirring for 16 h the reaction mixture was concentrated. The title compound was isolated by reverse phase HPLC. LCMS (M+H): 489.3. 1H NMR (400 MHz, CD3OD): δ 8.80 (s, 1H), 8.22 (s, 1H), 7.67 s, 1H), 7.50 (m, 2H), 4.79 (m, 1H), 4.45–4.20 (m, 5H), 3.91 (m, 3H), 2.61 (m, 1H), 2.21 (m, 1H), 1.87–1.72 (m, 5H), 1.37–1.17 (m, 5H).

Provenance & Evidence