HCID 13966776, compound → HCID 21866184, compound

Participants

Reaction Steps

The title compound was prepared from diethyl-3-isopropylpyrrolidine-2,2-dicarboxylate (3.06 g, 12.0 mmol) essentially according to the basic hydrolysis procedure described in Morgan, B. A.; Schafer, D. J. U.S. Pat. No. 4,060,603, Nov. 29, 1977 for the preparation of 3-ethyl-dl-proline from 2,2-dicarboethoxy-3-ethylpyrrolidine. The product was isolated as a yellow solid. LCMS (M+H): 158.0. 1H NMR (CD3OD, 400 MHz): δ 3.70 (d, J=6.4 Hz, 1 H), 3.31–3.27 (m, 1 H), 2.29–2.22 (m, 1 H), 2.08–1.99 (m, 1 H), 1.94–1.74 (m, 3 H), 1.05 (d, J=6.8 Hz), 0.97(d, J=6.8Hz, 3 H).

Provenance & Evidence