HCID 21866311, compound → 3-Propan-2-yl-L-proline

Participants

Reaction Conditions

Reaction Steps

A solution of diethyl-3-isopropylpyrrolidine-2,2-dicarboxylate (Example 39, Step A, 2.27 g, 8.81 mmol) in 6 M HCl (50 mL) was heated to reflux. The solution turned from pale yellow in color to orange with addition of acid, then to brown upon heating. The mixture was stirred overnight at 50° C. Solvent was removed in vacuo to afford the title compound (a mixture of four diastereomers) as a brown oil which was carried on crude. LCMS (M+H): 158.0.

Provenance & Evidence