Hydrochloric Acid → HCID 178523017, compound

Participants

Reaction Steps

Through a solution of tert-butyl (2S)-2-({[5-chloro-2-(1H-tetraazol-1-yl)benzyl]amino}carbonyl)azetidine-1-carboxylate (467 mg, 1.19 mmol) in EtOAc (24.0 mmol) at 0° C. was bubbled HCl (g) for 10 min. The solvent was removed in vacuo to give the title compound as a yellow solid. LCMS (M+H): 293.0. 1H NMR (CD3OD, 400 MHz): δ 9.57 (s, 1 H), 7.72–7.70 (m, 1 H), 7.64–7.59 (m, 1 H), 7.54–7.52 (m, 1 H), 4.96–4.92 (m, 1 H), 4.34–4.21 (m, 2 H), 4.13–4.06 (m, 1 H), 3.97–3.90 (m, 1 H), 2.81–2.75 (m, 1 H), 2.51–2.45 (m, 1 H).

Provenance & Evidence