HCID 17784962, compound → HCID 86227205, compound

HRID 857841Notes

Reaction equation

HRID 857841 reaction equation
[CH3:1][Si:2]([CH3:17])([CH3:16])[O:3][CH2:4][CH2:5][CH2:6][C:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH:8]=1.C([Li:22])CCC>CCOCC.CCCCCC>[CH3:17][Si:2]([CH3:1])([CH3:16])[O:3][CH2:4][CH2:5][CH2:6][C-:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8]1.[Li+:22]

Participants

5

Reactant 2

HCID 17784962HCID 17784962, compoundHCID 178418339Butyllithium

Product 1

HCID 86227205HCID 86227205, compoundYield 85%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8058HexaneSolvent

Procedure

To 1.5 g (6.1 mmol) of [3-(3-trimethylsiloxypropyl)indene] in ether at −78° C, 2.44 ml (6.1 mmol) of a 2.5 M butyllithium solution in hexane was added. The immediate formation of a white solid was observed. The mixture was maintained under stirring for 2 h. Then, the solvent was removed under vacuum and the residue was washed twice with 25 ml of hexane to give a brown solid. (1.3 g, 5.2 mmol, yield 85%).

Workup

  1. temperatureThe mixture was maintained
  2. customThen, the solvent was removed under vacuum
  3. washthe residue was washed twice with 25 ml of hexane
  4. customto give a brown solid

Sources & evidence

ORD record
ord-28ff20f24d7f4ead877a5349e44381b8
Source dataset
uspto-grants-2006_12
Patent number
US07148173B2

Reaction notes

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