Thionyl Chloride → 5-(2-Pyridinyl)-2-thiophenecarbonyl chloride

Participants

Reaction Conditions

Reaction Steps

A suspension of 5-(pyrid-2-yl)thiophene-2-carboxylic acid (48 mg) in dry toluene (10 mL) was treated with thionyl chloride (269 μL). After stirring at 100° C. for 2.5 hours the reaction mixture was allowed to cool to room temperature and then evaporated. The residue was azeotroped with toluene to give the title compound (61 mg), which was used without further purification.

Provenance & Evidence