HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Amino-4,6-dichloropyrimidin-5-yl)ethanol → HCID 58762825, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Amino-4,6-dichloropyrimidin-5-yl)ethanol | HCID 86598347 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 58762825 | HCID 58762825 | 71% |
Reaction Steps
1-(2-Amino-4,6-dichloro-pyrimidin-5-yl)-ethanol (2.0 g, 9.6 mmol) was treated with MnO2 (20 g, 229 mmol, 24 equiv.) in 1,2-dichloroethane for 16 h at 70° C. Filtration over celite and concentration gave 1-(2-Amino-4,6-dichloro-pyrimidin-5-yl)-ethanone as a pale orange solid (1.4 g, 6.7 mmol, 71%), which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07148228B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-986ca91ea9c345319589e61209d52613 |
| Source note | uspto-grants-2006_12 |