反应详情

1-(2-Amino-4,6-dichloro-pyrimidin-5-yl)-ethanone (200 mg, 0.97 mmol) was dissolved in CH2Cl2 and treated with anhydrous hydrazine (31 mg, 0.97 mmol, 1 equiv.) at r.t. overnight. The precipitate was collected by filtration, washed with CH2Cl2, dissolved in DMSO (0.5 mL), and partitioned between EtOAc (100 mL) and water (25 mL). The organic layer was dried (brine, Na2SO4) and concentrated to afford the title compound as a white solid (95 mg, 0.52 mmol, 53%).

1. filtrationThe precipitate was collected by filtration
2. washwashed with CH2Cl2
3. dissolutiondissolved in DMSO (0.5 mL)
4. custompartitioned between EtOAc (100 mL) and water (25 mL)
5. dry with materialThe organic layer was dried (brine, Na2SO4)
6. concentrationconcentrated