HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 857935Generated: October 31, 2026
Dimethylformamide → HCID 58762794, compound
https://huagongshe.com/reaction/857935
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(Chloromethyl)-3,5-dimethyl-4-methoxypyridine hydrochloride | HCID 11694258 | — |
| Reactant | 4-chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine | HCID 11789625 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 58762794 | HCID 58762794 | 17.2% |
Reaction Steps
A mixture of 4-chloro-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine (1.76 g), 2-chloromethyl-4-methoxy-3,5-dimethyl-pyridine hydrochloride (3.70 g), K2CO3 (5.17 g), and DMF (20 ml) was heated to 80° C. for 30 min, diluted with EtOAc, washed with water and brine, concentrated, and purified by flash chromatography to give the title compound as a white solid (0.57 g). R.t. 4.46 min. 1H-NMR (CDCl3) δ 8.10 (s, 1H), 7.89 (s, 1H), 5.53 (2H), 5.24 (br. s, 2H), 3.74 (s, 3H), 2.27 (s, 3H), 2.22 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07148228B2 |
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| Source dataset | uspto-grants-2006_12 |
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| ORD ID | ord-8e707cb75ce446c09388e22b47f93c4e |
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| Source note | uspto-grants-2006_12 |
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