HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 857936Generated: November 1, 2026
Cesium carbonate → 4-Chloro-1-(6-chloro-4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine
https://huagongshe.com/reaction/857936
Participants
| Role | Name | HCID | Charge |
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| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine | HCID 11789625 | — |
| Reactant | 2-Chloro-6-(chloromethyl)-4-methoxy-3,5-dimethylpyridine | HCID 21882889 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Chloro-1-(6-chloro-4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine | HCID 58878116 | — |
Reaction Steps
A mixture of 4-chloro-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine (124 mg), Cs2CO3 (392 mg) and crude 2-chloro-6-chloromethyl-4-methoxy-3,5-dimethyl-pyridine (200 mg) in DMF (2 ml) was heated to 80° C. for 1 h, diluted with EtOAc and washed with water. Concentration and purification by preparative TLC (EtOAc) gave the title compound. R.t. 6.43 min. 1H-NMR (CDCl3) δ 7.86 (s, 1H), 5.48 (s, 2H), 5.37 (s, 2H), 3.71 (s, 3H), 2.27 (s, 3H), 2.15 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07148228B2 |
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| Source dataset | uspto-grants-2006_12 |
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| ORD ID | ord-e091141bf5ad42fda4aa5a4240fce9d6 |
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| Source note | uspto-grants-2006_12 |
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