Formamide → HCID 135553012, compound

HRID 858024Notes

Reaction equation

HRID 858024 reaction equation
[NH2:1][C:2]1[C:10]([Br:11])=[CH:9][C:8]([Cl:12])=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:13]([NH2:15])=O>>[Br:11][C:10]1[CH:9]=[C:8]([Cl:12])[CH:7]=[C:3]2[C:2]=1[N:1]=[CH:13][NH:15][C:4]2=[O:5]

Participants

3

Reactant 2

HCID 713FormamideHCID 117799312-Amino-3-bromo-5-chlorobenzoic acid

Product 1

HCID 135553012HCID 135553012, compound

Procedure

8-Bromo-6-chloro-4(3H)quinazolinone was prepared from 2-amino-3-bromo-5-chlorobenzoic acid (10 g, 40 mmol). The acid was heated in excess formamide (50 mL) at reflux overnight. The mixture was cooled and quenched with water. The solid that formed was washed with acetonitrile, 6.7 g crude (65%); MS: 260.8 (M+H)+

Workup

  1. temperatureat reflux overnight
  2. temperatureThe mixture was cooled
  3. customquenched with water
  4. customThe solid that formed
  5. washwas washed with acetonitrile, 6.7 g crude (65%)

Sources & evidence

ORD record
ord-6a891242028a4f4792d3a699571d7d59
Source dataset
uspto-grants-2006_12
Patent number
US07148235B2

Reaction notes

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