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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 858042Generated: October 25, 2026

1-methyl-1H-pyrazole-4-sulfonyl chloride → N-(4-((1-(2-fluorobenzyl)-3-(cyclopropylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)methyl)phenyl)-1-methyl-1H-pyrazole-4-sulfonamide

https://huagongshe.com/reaction/858042

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-methyl-1H-pyrazole-4-sulfonyl chlorideHCID 17024730—
Reactant3-Cyclopropylmethyl-8-[4-aminobenzyl]-1-(2-fluorobenzyl)-3,7-dihydro-purine-2,6-dioneHCID 21891737—
ProductN-(4-((1-(2-fluorobenzyl)-3-(cyclopropylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)methyl)phenyl)-1-methyl-1H-pyrazole-4-sulfonamideHCID 10482987—

Reaction Steps

Prepared from 8-(4-amino-benzyl)-3-cyclopropylmethyl-1-(2-fluoro-benzyl)-3,7-dihydro-purine-2,6-dione and 1-methyl-1H-pyrazole-4-sulfonyl chloride. Off-white solid; EI-HRMS m/e calculated for C27H26FN7O4S (M+) 563.1751, found 563.1752.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07148229B2
Source datasetuspto-grants-2006_12
ORD IDord-aacab4fccd064731837aada2782e762c
Source noteuspto-grants-2006_12