2-(4-(TERT-BUTOXYCARBONYL(METHYL)AMINO) PHENYL)ACETIC ACID → HCID 58762829, compound

HRID 858057Notes

Reaction equation

HRID 858057 reaction equation
[C:1]([O:5][C:6](=[O:35])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][C:15](=[O:34])[NH:16][C:17]2[C:18](=[O:33])[N:19]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[F:32])[C:20](=[O:24])[NH:21][C:22]=2[NH2:23])=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[C:36](OC(N(C)C1C=CC(CC(O)=O)=CC=1)=O)(C)(C)C>>[C:1]([O:5][C:6](=[O:35])[N:7]([C:8]1[CH:9]=[CH:10][C:11]([CH2:14][C:15](=[O:34])[NH:16][C:17]2[C:18](=[O:33])[N:19]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[F:32])[C:20](=[O:24])[NH:21][C:22]=2[NH2:23])=[CH:12][CH:13]=1)[CH3:36])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 107303972-(4-(TERT-BUTOXYCARBONYL(METHYL)AMINO) PHENYL)ACETIC ACIDHCID 58762847HCID 58762847, compound

Product 1

HCID 58762829HCID 58762829, compound

Procedure

Prepared by the same procedure as described for the preparation of (4-{[6-amino-3-(2-fluoro-benzyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl]-methyl}-phenyl)-carbamic acid tert-butyl ester (example 1, step 4) except that [4-(tert-butoxycarbonyl-methyl-amino)-phenyl]-acetic acid was used in place of (4-tert-butoxycarbonylamino-phenyl)-acetic acid. Crude (4-{[6-amino-3-(2-fluoro-benzyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl]-methyl}-phenyl)-methyl-carbamic acid tert-butyl ester was obtained as a yellow solid which was of sufficient purity for subsequent used without additional purification.

Workup

  1. customPrepared by the same procedure

Sources & evidence

ORD record
ord-1e3045f3385e4ac199e931ccc42dec75
Source dataset
uspto-grants-2006_12
Patent number
US07148229B2

Reaction notes

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