8-Quinolinesulfonyl chloride → HCID 11758437, compound

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Reaction Steps

This compound was prepared by the routes shown in schemes 2 and 4. 8-(4-Amino-benzyl)-3-cyclopropylmethyl-1-(2-fluoro-benzyl)-3,7-dihydro-purine-2,6-dione was condensed with 8-quinolinesulfonyl chloride under standard conditions to give the stated sulfonamide. Recrystallization from acetonitrile gave the pure product as an off white solid (53%); 1H NMR(DMSO-d6, 300 MHz) δH13.45 (s, 1H), 10.12 (s, 1H), 9.21 (dd, J=4.2, 1.1 Hz, 1H), 8.59 (dd, J=8.4, 1.8 Hz, 1H), 8.41 (dd, J=7.3, 1.5 Hz, 1H), 8.33 (dd, J=7.7, 1.5 Hz, 1H), 7.82–7.73 (m, 2H), 7.45–7.00 (m, 8H), 5.16 (s, 2H), 3.93 (s, 2H), 3.86 (d, J=7.3 Hz, 2H), 1.30–1.10 (m, 1H) and 0.50–0.30 (m, 4H); EI-HRMS m/e calculated for C32H27FN6O4S (M+) 610.1798, found 610.1804.

Provenance & Evidence