N-Acetylsulfanilyl chloride → HCID 10394040, compound

Participants

Reaction Steps

8-(4-Amino-benzyl)-3-cyclopropylmethyl-1-(2-fluoro-benzyl)-3,7-dihydro-purine-2,6-dione was condensed with 4-acetamidobenzenesulfonyl chloride under the conditions previously described to give the stated sulfonamide. Recrystallized from acetonitrile to give the pure product as an off-white solid (68%); 1H NMR (DMSO-d6, 300 MHz) δH13.53 (s, 1H), 10.36 (s, 1H), 10.23 (s, 1H), 7.75 (s, 4H), 7.40–7.05 (m, 8H), 5.19 (s, 2H), 4.02 (s, 2H), 3.91 (d, J=7.0 Hz, 2H), 2.13 (s, 3H), 1.35–1.15 (m, 1H) and 0.55–0.35 (m, 4H); EI-HRMS m/e calculated for C31H29FN6O5S (M+) 616.1904, found 616.1922.

Provenance & Evidence