Methanesulfonyl chloride → HCID 10097381, compound

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8-(4-Amino-benzyl)-3-cyclopropylmethyl-1-(2-fluoro-benzyl)-3,7-dihydro-purine-2,6-dione was condensed with methanesulfonyl chloride under the conditions previously described to give the stated sulfonamide as an off-white solid (28%); 1H NMR(DMSO-d6, 300 MHz) δH 13.42 (s, 1H), 9.61 (s, 1H), 7.30–6.90 (m, 8H), 5.04 (s, 2H), 3.94 (s, 2H), 3.77 (d, J=6.6 Hz, 2H), 2.87 (s, 3H), 1.25–1.05 (m, 1H), 0.40–0.25 (m, 4H); EI-HRMS m/e calculated for C24H24FN5O4S (M+) 497.1533, found 497.1528.

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