Methanesulfonyl chloride → HCID 10367941, compound

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8-(4-Amino-benzyl)-1-benzyl-3-butyl-3,7-dihydro-purine-2,6-dione was condensed with methanesulfonyl chloride under the conditions previously described to give the stated sulfonamide as a pale brown solid (35%); 1H NMR(DMSO-d6, 300 MHz) δH13.54 (s, 1H), 9.76 (s, 1H), 7.45–7.25 (m, 7H), 7.22 (d, J=8.4 Hz, 2H), 5.14 (s, 2H), 4.10 (s, 2H), 4.04 (t, J=7.1 Hz, 2H), 3.03 (s, 3H), 1.80–1.65 (m, 2H), 1.40–1.25 (m, 2H), 0.96 (t, J=7.3 Hz, 3H); EI-HRMS m/e calculated for C24H27N5O4S (M+) 481.1784, found 481.1781.

Provenance & Evidence