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HRID858069

反应详情

EQUATION

反应方程式

HRID 858069 的结构方程式

REACTANTS

反应物

3
结构：CCCCn1c(N)c(N)c(=O)n(Cc2ccccc2F)c1=O
HCID21891756

未命名化合物

结构：Cc1nn(C)c(Cl)c1S(=O)(=O)Nc1ccc(CC(=O)O)nc1
HCID58762844

未命名化合物

结构：CC(=O)Nc1nc(C)c(S(=O)(=O)Nc2ccc(CC(=O)Nc3c(N)n(CC4CC4)c(=O)n(Cc4ccccc4F)c3=O)cc2)s1
HCID58762848

未命名化合物

PRODUCTS

生成物

1
结构：CCCCn1c(N)c(NC(=O)Cc2ccc(NS(=O)(=O)c3c(C)nn(C)c3Cl)cn2)c(=O)n(Cc2ccccc2F)c1=O
HCID58762841

未命名化合物

PROCEDURE

实验过程

Prepared as for 2-[4-(2-acetylamino-4-methyl-thiazole-5-sulfonylamino)-phenyl]-N-[6-amino-1-cyclopropylmethyl-3-(2-fluoro-benzyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetamide (example 10, step 1) except using [5-(5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonylamino)-pyridin-2-yl]-acetic acid and 5,6-diamino-1-butyl-3-(2-fluoro-benzyl)-1H-pyrimidine-2,4-dione. N-[6-amino-1-butyl-3-(2-fluoro-benzyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-2-[5-(5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonylamino)-pyridin-2-yl]-acetamide was used without purification (91%); LRMS for C27H30ClFN8O5S (M+H)+ at m/z=633/635.

WORKUP

后处理

  1. customN-[6-amino-1-butyl-3-(2-fluoro-benzyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-2-[5-(5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonylamino)-pyridin-2-yl]-acetamide was used without purification (91%)