HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 858084Generated: October 30, 2026
5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonyl chloride → N-(4-((1-(2-fluorobenzyl)-3-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)methyl)phenyl)-5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonamide
https://huagongshe.com/reaction/858084
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonyl chloride | HCID 2777126 | — |
| Reactant | 1-(2-fluorobenzyl)-8-(4-aminobenzyl)-3-butyl-1H-purine-2,6(3H,7H)-dione | HCID 21891720 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-(4-((1-(2-fluorobenzyl)-3-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)methyl)phenyl)-5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonamide | HCID 10438766 | — |
Reaction Steps
8-(4-Amino-benzyl)-3-butyl-1-(2-fluoro-benzyl)-3,7-dihydro-purine-2,6-dione (20 mg, 0.047 mmol) was dissolved in pyridine (0.5 ml) and treated with 5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonyl chloride (Maybridge, 16 mg, 0.07 mmol). The reaction was stirred at 23° C. for 3 h. The solvent was removed and the residue was purified by reverse phase HPLC. LCMS, m/z (M+H)=615.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07148229B2 |
|---|
| Source dataset | uspto-grants-2006_12 |
|---|
| ORD ID | ord-0e6df2be4e8649699c6cae2f33840140 |
|---|
| Source note | uspto-grants-2006_12 |
|---|
