5-Fluoro-2-methylbenzenesulphonyl chloride → HCID 10483613, compound

HRID 858120Notes

Reaction equation

HRID 858120 reaction equation
[NH2:1][C:2]1[CH:31]=[CH:30][C:5]([CH2:6][C:7]2[NH:15][C:14]3[C:13](=[O:16])[N:12]([CH2:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[F:24])[C:11](=[O:25])[N:10]([CH2:26][CH2:27][CH2:28][CH3:29])[C:9]=3[N:8]=2)=[CH:4][CH:3]=1.[F:32][C:33]1[CH:34]=[CH:35][C:36]([CH3:43])=[C:37]([S:39](Cl)(=[O:41])=[O:40])[CH:38]=1>>[CH2:26]([N:10]1[C:9]2[N:8]=[C:7]([CH2:6][C:5]3[CH:4]=[CH:3][C:2]([NH:1][S:39]([C:37]4[CH:38]=[C:33]([F:32])[CH:34]=[CH:35][C:36]=4[CH3:43])(=[O:40])=[O:41])=[CH:31][CH:30]=3)[NH:15][C:14]=2[C:13](=[O:16])[N:12]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])[C:11]1=[O:25])[CH2:27][CH2:28][CH3:29]

Participants

3

Reactant 2

HCID 1362865-Fluoro-2-methylbenzenesulphonyl chlorideHCID 218917201-(2-fluorobenzyl)-8-(4-aminobenzyl)-3-butyl-1H-purine-2,6(3H,7H)-dione

Product 1

HCID 10483613HCID 10483613, compound

Procedure

Prepared from 8-(4-amino-benzyl)-3-butyl-1-(2-fluoro-benzyl)-3,7-dihydro-purine-2,6-dione and 5-fluoro-2-methyl-benzenesulfonyl chloride. Purity (ELSD, based on MW=593.7)=92%.

Sources & evidence

ORD record
ord-71c27173af614b58aaeff861fc75eafd
Source dataset
uspto-grants-2006_12
Patent number
US07148229B2

Reaction notes

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