Sodium methanethiolate → HCID 69513751, compound

Participants

Reaction Steps

To a suspension of compound from step (ii) (472 mg, 1.69 mmol) in MeOH (17 mL), a solution of sodium thiomethoxide (130 mg, 1.86 mmol) in MeOH (4 mL) was added at room temperature. The reaction mixture was allowed to stir at rt, under nitrogen atmosphere overnight. Then it was concentrated in vacuo and a 0.1 M solution of HCl (30 mL) and CH2Cl2 were added. The layers were separated and the aqueous phase was extracted with CH2Cl2. The combined organic phase was dried over MgSO4, filtered and CIV to afford 315 mg (79%) of the final compound as a white solid.

Provenance & Evidence