Water → HCID 69524090, compound

Participants

Reaction Steps

To a solution of N-{4-[(8-methyl-8-azabicylo[3.2.1]oct-3-yl)thio]phenyl]-3-thiophenecarboxamide (130 mg) in methanol (5 ml) was added a solution of Oxone (446 mg) in water. The mixture was stirred at room temperature for 30 minutes and then applied directly to an SCX cartridge. The impure product eluted with methanol and was subjected to further clean up by preparative LC-MS to yield N-{4-[(8-methyl-8-azabicylo[3.2.1]oct-3-yl)sulfonyl]phenyl]-3-thiophenecarboxamide (75 mg).

Provenance & Evidence