Potassium tert-butoxide → HCID 178420783, compound

HRID 858176Notes

Reaction equation

HRID 858176 reaction equation
Cl.Cl.Cl[CH:4]([CH2:16][N:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)[CH2:5][O:6][NH:7][C:8]([C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)=[NH:9].CC(C)([O-])C.[K+]>C(O)(C)(C)C>[N:17]1([CH2:16][CH:4]2[CH2:5][O:6][N:7]=[C:8]([C:10]3[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=3)[NH:9]2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 178478847HCID 178478847, compound

Product 1

HCID 178420783HCID 178420783, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

13.2 g (35.7 mmol) of N-[2-chloro-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide dihydrochloride was added to a solution of 16.5 g (143.5 mmole) of potassium tert-butoxide dissolved in 150 ml of tert-butanol. The mixture was boiled for 6 hours, then evaporated in vacuum. 100 ml of 5% sodium hydroxide solution was added and the mixture was extracted three times with 300 ml portions of ethyl acetate.

Workup

  1. customevaporated in vacuum
  2. addition100 ml of 5% sodium hydroxide solution was added
  3. extractionthe mixture was extracted three times with 300 ml portions of ethyl acetate

Sources & evidence

ORD record
ord-b1ac0b3edf2b4ff8b49afe8d2c4a1ab8
Source dataset
uspto-grants-2006_12
Patent number
US07148239B2

Reaction notes

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