HCID 86594505, compound → 5-(2-{cis-3-[2-(4-Fluorophenyl)-5-methyloxazol-4-ylmethoxy]cyclohexyl-oxy}ethyl)thiazolidine-2,4-dione

HRID 858200Notes

Reaction equation

HRID 858200 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:31])=[C:11]([CH2:13][O:14][C@@H:15]3[CH2:20][CH2:19][CH2:18][C@H:17]([O:21][CH2:22][CH:23]=[C:24]4[S:28][C:27](=[O:29])[NH:26][C:25]4=[O:30])[CH2:16]3)[N:12]=2)=[CH:4][CH:3]=1.[H][H]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:31])=[C:11]([CH2:13][O:14][C@@H:15]3[CH2:20][CH2:19][CH2:18][C@H:17]([O:21][CH2:22][CH2:23][CH:24]4[S:28][C:27](=[O:29])[NH:26][C:25]4=[O:30])[CH2:16]3)[N:12]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 86594505HCID 86594505, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 865945065-(2-{cis-3-[2-(4-Fluorophenyl)-5-methyloxazol-4-ylmethoxy]cyclohexyl-oxy}ethyl)thiazolidine-2,4-dione

Procedure

Hydrogenation of the compound 5-(2-{cis-3-[2-(4-fluorophenyl)-5-methyloxazol-4-ylmethoxy]cyclohexyloxy}ethylidene)thiazolidine-2,4-dione, mentioned in Example Example XXII, with hydrogen gives the compound 5-(2-{cis-3-[2-(4-fluorophenyl)-5-methyloxazol-4-ylmethoxy]cyclohexyl-oxy}ethyl)thiazolidine-2,4-dione:

Sources & evidence

ORD record
ord-1540b076982b4d86bbd40768c0c2a8f3
Source dataset
uspto-grants-2006_12
Patent number
US07148246B2

Reaction notes

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