7-Bromo-5-methoxy-2-(4-methoxyphenyl)-1,3-benzoxazole → HCID 21907383, compound

HRID 858253Notes

Reaction equation

HRID 858253 reaction equation
Br[C:2]1[C:10]2[O:9][C:8]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[N:7][C:6]=2[CH:5]=[C:4]([O:19][CH3:20])[CH:3]=1>CC(C)=O>[CH3:20][O:19][C:4]1[CH:3]=[C:2]([C:10]([OH:9])([CH3:2])[CH3:6])[C:10]2[O:9][C:8]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[N:7][C:6]=2[CH:5]=1

Participants

3

Reactant 1

HCID 121489697-Bromo-5-methoxy-2-(4-methoxyphenyl)-1,3-benzoxazole

Product 1

HCID 21907383HCID 21907383, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The title compound was prepared according to the procedure of Example 43, Step a, from 7-bromo-5-methoxy-2-(4-methoxyphenyl)-1,3-benzoxazole, employing acetone as the electrophile, to give a white solid (78% yield, m.p. 149° C.); MS m/e 314 (M+H)+.

Sources & evidence

ORD record
ord-cc91789f1b4e41108b87d34d9c331822
Source dataset
uspto-grants-2006_12
Patent number
US07148247B2

Reaction notes

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