3,5-Difluoro-4-methoxybenzoic acid → 7-Bromo-2-(3,5-difluoro-4-hydroxyphenyl)-1,3-benzoxazol-5-ol

HRID 858260Notes

Reaction equation

HRID 858260 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([F:13])[C:10]=1[O:11]C)[C:5]([OH:7])=O.[NH2:14][C:15]1[CH:20]=[C:19]([O:21]C)[CH:18]=[C:17]([Br:23])[C:16]=1O>>[Br:23][C:17]1[C:16]2[O:7][C:5]([C:4]3[CH:8]=[C:9]([F:13])[C:10]([OH:11])=[C:2]([F:1])[CH:3]=3)=[N:14][C:15]=2[CH:20]=[C:19]([OH:21])[CH:18]=1

Participants

3

Reactant 2

HCID 27369873,5-Difluoro-4-methoxybenzoic acidHCID 111719822-Amino-6-Bromo-4-Methoxyphenol

Product 1

HCID 1363472837-Bromo-2-(3,5-difluoro-4-hydroxyphenyl)-1,3-benzoxazol-5-ol

Procedure

The title compound was prepared in substantially the same manner as described in Example 21, from 3,5-difluoro-4-methoxybenzoic acid, and 2-amino-6-bromo-4-methoxyphenol, and was obtained as a white solid, m.p. 270–272° C.; MS m/e 340 (M−H)+.

Workup

  1. customwas obtained as a white solid, m.p. 270–272° C.

Sources & evidence

ORD record
ord-fd8a51fcb77745faa617e65c9c98bb5d
Source dataset
uspto-grants-2006_12
Patent number
US07148247B2

Reaction notes

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