Chloromethyl Methyl Ether → 1-Bromo-3-(methoxymethoxy)benzene

HRID 858266Notes

Reaction equation

HRID 858266 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[CH3:9][O:10][CH2:11]Cl>>[CH3:9][O:10][CH2:11][O:8][C:4]1[CH:3]=[C:2]([Br:1])[CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 7864Chloromethyl Methyl EtherHCID 115633-Bromophenol

Product 1

HCID 103309501-Bromo-3-(methoxymethoxy)benzeneYield 107.9%

Procedure

In a manner similar to that of Example 7(a), by reaction of 100.00 g (577.9 mmol) of 3-bromophenol with 48.28 g (635.8 mmol) of chloromethyl methyl ether, 135.32 g (100%) of the expected product are obtained in the form of a pale beige oil.

Sources & evidence

ORD record
ord-fdbb3fe0129c494a9d35f42463db17db
Source dataset
uspto-grants-2006_12
Patent number
US07148245B2

Reaction notes

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