2-Bromophenol → 1-Bromo-2-(methoxymethoxy)benzene

HRID 858267Notes

Reaction equation

HRID 858267 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].[CH3:9][O:10][CH2:11]Cl>>[CH3:9][O:10][CH2:11][O:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Br:1]

Participants

3

Reactant 2

HCID 72442-BromophenolHCID 7864Chloromethyl Methyl Ether

Product 1

HCID 113104791-Bromo-2-(methoxymethoxy)benzeneYield 100%

Procedure

In a manner similar to that of Example 7(a), by reaction of 15.00 g (86.7 mmol) of 2-bromophenol with 8.40 g (104.0 mmol) of chloromethyl methyl ether, 18.80 g (100%) of the expected product are obtained in the form of a beige-coloured oil.

Sources & evidence

ORD record
ord-58afa00ea6f74103a5f4de30c284e8eb
Source dataset
uspto-grants-2006_12
Patent number
US07148245B2

Reaction notes

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