HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Fluoro-2-nitrophenyl)acetic acid → 6-fluoro-2,3-dihydro-1H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Fluoro-2-nitrophenyl)acetic acid | HCID 10750492 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 6-fluoro-2,3-dihydro-1H-indol-2-one | HCID 3731013 | — |
Reaction Steps
119 g 4-fluoro-2-nitrophenylacetic acid are hydrogenated in 600 ml acetic acid with the addition of 20 g palladium on activated charcoal (10%) under 50 psi of hydrogen pressure. The catalyst is suction filtered, the solvent distilled off. The crude product is stirred with 500 ml petroleum ether, suction filtered, washed with water and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07148249B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-50accfa8a926434eb75cd21f6a211fbe |
| Source note | uspto-grants-2006_12 |