Acetic Anhydride → 1-Acetyl-6-fluoro-1,3-dihydro-2H-indol-2-one

HRID 858296Notes

Reaction equation

HRID 858296 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[C:12]([N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([F:1])[CH:10]=2)[CH2:6][C:7]1=[O:11])(=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 37310136-fluoro-2,3-dihydro-1H-indol-2-one

Product 1

HCID 581603571-Acetyl-6-fluoro-1,3-dihydro-2H-indol-2-one

Procedure

82.5 g of 6-fluoro-2-indolinone are stirred in 180 ml acetic anhydride for 3 hours at 130° C. After cooling to ambient temperature the precipitate is suction filtered, washed with 100 ml petroleum ether and dried.

Workup

  1. filtrationfiltered
  2. washwashed with 100 ml petroleum ether
  3. customdried

Sources & evidence

ORD record
ord-b06deff4232f405b8dc68f7946d02f4c
Source dataset
uspto-grants-2006_12
Patent number
US07148249B2

Reaction notes

Loading…