HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178473971, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Furancarbonyl chloride | HCID 68242 | — |
| Reactant | 1-Acetylindolin-2-one | HCID 323719 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178473971 | HCID 178473971 | — |
Reaction Steps
An ice-cooled solution of 7.0 g 1-acetyl-2-indolinone and 10.8 g DMAP in 60 ml DMF is combined with 4.4 ml of furan-2-carboxylic acid chloride. The mixture is stirred for 1 hour at ambient temperature, then poured onto 40 ml of conc. hydrochloric acid and 500 ml ice water. The precipitate is suction filtered, washed successively with ethanol and diethyl ether and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07148249B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-6a96b209c8f6498381fc30eceff997cb |
| Source note | uspto-grants-2006_12 |