Phosphorus pentachloride → HCID 68846062, compound

HRID 858302Notes

Reaction equation

HRID 858302 reaction equation
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([Cl:13])[CH:11]=2)[C:6](=[C:14](O)[C:15]2[NH:16][CH:17]=[CH:18][CH:19]=2)[C:5]1=[O:21])(=[O:3])[CH3:2].P(Cl)(Cl)(Cl)(Cl)[Cl:23]>O1CCOCC1.C1(C)C=CC=CC=1>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([Cl:13])[CH:11]=2)[C:6](=[C:14]([Cl:23])[C:15]2[NH:16][CH:17]=[CH:18][CH:19]=2)[C:5]1=[O:21])(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 178473970HCID 178473970, compound

Product 1

HCID 68846062HCID 68846062, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
90 °C

Procedure

A suspension of 4.5 g of 1-acetyl-6-chloro-3-[1-hydroxy-1-(2-pyrrolyl)methylene]-2-indolinone and 3.4 g of phosphorus pentachloride in 50 ml of dioxane and 50 ml of toluene is stirred for 3 hours at 90° C. Then the solvent is distilled off and the residue is purified by chromatography on silica gel (eluant: toluene).

Workup

  1. distillationThen the solvent is distilled off
  2. customthe residue is purified by chromatography on silica gel (eluant: toluene)

Sources & evidence

ORD record
ord-7f302500e3154b70b635b6653b694682
Source dataset
uspto-grants-2006_12
Patent number
US07148249B2

Reaction notes

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