Formic Acid → HCID 68843591, compound

HRID 858306Notes

Reaction equation

HRID 858306 reaction equation
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:13])[CH:11]=2)[C:6](=[C:14]([O:26][CH3:27])[C:15]2[CH:20]=[CH:19][C:18]([NH:21][CH3:22])=[C:17]([N+:23]([O-])=O)[CH:16]=2)[C:5]1=[O:28])(=[O:3])[CH3:2].[H][H].[CH:31](O)=O>[Ni]>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:13])[CH:11]=2)[C:6](=[C:14]([O:26][CH3:27])[C:15]2[CH:20]=[CH:19][C:18]3[N:21]([CH3:31])[CH:22]=[N:23][C:17]=3[CH:16]=2)[C:5]1=[O:28])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 284Formic AcidHCID 68848640HCID 68848640, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68843591HCID 68843591, compound

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

0.40 g of 1-acetyl-6-fluoro-3-[1-methoxy-1-(4-methylamino-3-nitrophenyl)methylene]-2-indolinone are hydrogenated in 5.0 ml formic acid with the addition of 0.20 g of Raney nickel for 3 hours under 50 psi of hydrogen atmosphere. The catalyst is eliminated by suction filtering and the filtrate is evaporated down. The residue is stirred with diethyl ether, then after crystallisation suction filtered and dried.

Workup

  1. filtrationfiltering
  2. customthe filtrate is evaporated down
  3. customafter crystallisation suction
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-ed6ced0ed905429d8706972009726ca5
Source dataset
uspto-grants-2006_12
Patent number
US07148249B2

Reaction notes

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