(4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone → (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone

HRID 858308Notes

Reaction equation

HRID 858308 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][CH:11]=2)=[O:9])[CH2:4][CH2:3]1.[H][H]>C(O)C.[Ni]>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)=[O:9])[CH2:6][CH2:7]1

Participants

5

Reactant 2

HCID 716396(4-Methylpiperazin-1-yl)(4-nitrophenyl)methanoneHCID 178418361HCID 178418361, compound

Product 1

HCID 231408(4-Aminophenyl)(4-methylpiperazin-1-yl)methanone

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

10.9 g of 4-(1-methyl-4-piperazinyl-carbonyl)-1-nitrobenzene are hydrogenated in 90 ml of ethanol with the addition of 1.1 g of Raney nickel for 35 minutes at ambient temperature under 50 psi of hydrogen atmosphere. The catalyst is removed by suction filtering, the filtrate is evaporated down, the residue is stirred with diethyl ether and dried.

Workup

  1. customThe catalyst is removed by suction
  2. filtrationfiltering
  3. customthe filtrate is evaporated down
  4. customdried

Sources & evidence

ORD record
ord-1db9eeb7f2da4bd5a358076412b1bf2a
Source dataset
uspto-grants-2006_12
Patent number
US07148249B2

Reaction notes

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