Potassium Carbonate → HCID 18331486, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 2-hydroxy-4-methoxyphenyl-4-hydroxyphenyl ketone (2.6 grams, 10.65 mmol), 4-chlorophenylacetic acid (4.0 g, 23.43 mmol), K2CO3 (4.4 g, 31.95 mnol), carbonyldiimidazole (3.8 g, 23.43 m.mol), and 4-dimethylaminopyridine (0.1 g) in 20 mL of DMF was warmed at 90° C. for 5 hours. The reaction mixture was poured into 150 mL of H2O and stirred for 30 minutes. The precipitated product was collected by filtration and the purified desired product was isolated following flash chromatography (2.1 g, 52%, LC/MS=379 (M+H+)).

Provenance & Evidence