HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Benzo[b]thiophene-2-carbonyl Chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Benzo(b)thiophene-2-carboxylic acid | HCID 95864 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Benzo[b]thiophene-2-carbonyl Chloride | HCID 142384 | 23% |
Reaction Steps
Benzothiophene-2-carboxylic acid was treated with 1.5 equivalents of oxalyl chloride in dichloromethane in the presence of a catalytic amount of DMF to form benzothiophene-2-carbonyl chloride. Following procedures described for Example 1 and substituting this acyl chloride for 3-trifluoromethylbenzoyl chloride, compound 77 was prepared in 23% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07148259B1 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-f9a7d289cc7a449ba9a73787fd9dad37 |
| Source note | uspto-grants-2006_12 |