Ethylene Oxide → HCID 69361496, compound

HRID 858326Notes

Reaction equation

HRID 858326 reaction equation
Cl[CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([CH:10]([CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)[CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[CH2:6][CH2:5]1.C1(C(C2CCCCC2)N2CCNCC2)CCCCC1.C1[O:44]C1>>[OH:44][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([CH:10]([CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)[CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[CH2:6][CH2:5]1

Participants

4

Reactant 3

HCID 6354Ethylene OxideHCID 19701039HCID 19701039, compoundHCID 69359487HCID 69359487, compound

Product 1

HCID 69361496HCID 69361496, compound

Procedure

For example, 1-(2-chloroethyl)-4-dicyclohexylmethylpiperazine can be prepared by reacting N-dicyclohexylmethylpiperazine with ethylene oxide, to form 1-(2-hydroxyethyl)-4-dicyclohexylmethylpiperazine, which is subsequently treated with a chlorinating agent, such as thionyl chloride, to produce the desired compound.

Sources & evidence

ORD record
ord-7acf77c03f8a46dda680116373da8eea
Source dataset
uspto-grants-2006_12
Patent number
US07148240B2

Reaction notes

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