Gamma-Aminobutyric Acid → HCID 777180, compound

Participants

Reaction Steps

4-nitrophthalic anhydride (0.25 g, 0.0013 mol) and 4-aminobutyric acid (0.134 g, 0.0013 mol) were refluxed as above overnight. The clear solution was purified as per 120 to yield 0.35 g (98%) 142 as very pale yellow powder: mp=176–178° C.; Rf 0.82 (A): Rf 0.83 (B): Rf 0.71 (D): IR (cm−1): 3000–3300 (OH), 3122 (C═CH), 1775 (C═O), 1707 (bs, C═O), 1617 (C═C), 1545 (N═O), 1446 (C═C), 1399 (C—O), 1349 (N═O), 1167 (C—O), 722 (C—CH); MS m/z (rel intensity) 291 (100), 191 (8).

Provenance & Evidence